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KMID : 0369319940140020238
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Allergy
1994 Volume.14 No. 2 p.238 ~ p.245
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The Significance of Specific IgG Subclass to Chironomus Plumosus(CP) in CP-sensitive Patients.
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Abstract
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CP has been considered as one of the significant respiratory allergens in this country. To evaluate the significance of specific IgG subclass to CP in CP-sensitive patients (>2+responders on shin prick test), we measured specific IgE and IgG
subclass
(IgG1, IgG2, IgG3 and IgG4) to CP by enzyme-linked immunosorbent assay in 97 CP-sensitive patients´ sera, and control sera who showed all negative responses on skin prick test. There were no significant differences in absorbance values between
patients´
and control sera. No differences were noted according to allergic disease or the existence of CP-specific IgE antibody. High specific IgG4 bindings were noted in two cases of rhinitis and one of asthma who had no specific IgE binding. It is
suggested
that CP-specific IgG1, IgG2 and IgG3 antibody might be an immune response to exposure to CP. Further studies are needed to investigate the pathogenic role of specific IgG subclass to CP.
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KEYWORD
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